Thanks to the Green Mini Host (Apple Mac Mini hosting and collocation provider) who were the first to publicly confirm that latest release of ESXi (6.7 Update 1) works on the recently announced 2018 Apple Mac Mini.
— Green Mini host (@macminihost) November 7, 2018
For vSphere/vSAN Home Lab enthusiasts, the price of the new Mac Mini, especially when it is fully loaded is probably a tough sale. However, for customers developing on MacOS including iOS development, CI/CD, build farms, gaming, etc. which benefit from running on vSphere. For these customers, support for ESXi on the new Mac Mini is extremely interesting, especially with the updated hardware giving these systems a significant boost in performance even when comparing to the current Mac Pro 6,1 and iMac Pro models. In fact, I had number of folks ping me after Apple introduced it during their keynote asking if ESXi would work on the Mini's.
UPDATE (06/25/20) - The Apple 2018 Mac Mini 8,1 is now officially on the VMware HCL and is fully supported with ESXi 7.0b, which contains the fixes mentioned above. See note below on 06/23 for more information.
UPDATE (06/23/20) - ESXi 7.0b has just been released and contains fixes for both the MacOS guest boot issue support for Thunderbolt 3 devices which now enables support for the vSphere 7 release. One additional enhancement, customers no longer need to configure the ESXi Advanced Setting to enable Thunderbolt 3 support, this is now automatically configured based on detecting an Apple hardware system such as an Apple Mac Mini 2018 or Apple Mac Pro 2019. This is a patch release and you will need to go to the VMware Patch Portal site to download and apply the update.
UPDATE (04/28/20) - ESXi 6.7 Patch 02 resolves a number of the issues mentioned below, please take a look at this blog post here for more details.
Disclaimer: 2018 Apple Mac Mini are NOT officially supported by VMware. The only officially supported Apple hardware platform is the Mac Pro 6,1 or Mac Pro 5,1 and Mac Mini 6,2 or Mac Mini 7,1. For more details, please refer to VMware's Hardware Compatibility List.